
Key Takeaways
- 1. Rinse Immediately after Use:
- 2. Gentle Cleaning:
- 3. Drying and Storage:
Rinse your mouth guard under cool or lukewarm water after each use to remove saliva and debris.
Use a soft-bristled toothbrush (like a child's toothbrush or a denture brush) to gently scrub the mouthguard.
Avoid using harsh chemicals or abrasive toothpaste, as these can damage the material.
If using soap, choose a mild, unscented soap or a mild, non-abrasive toothpaste.
For a deeper clean, you can soak the mouthguard in a denture cleaning solution, but follow the instructions carefully and rinse thoroughly.
After cleaning, rinse the mouth guard thoroughly with cool or lukewarm water.
Allow the mouth guard to air dry completely before storing it.
Store the mouth guard in a clean, dry, and well-ventilated container to prevent bacterial growth and damage.
Avoid storing it in a hot, humid environment or direct sunlight.
Your mouth guard is like a quiet protector, standing guard over your smile while you sleep or play sports. No matter how you use it, your mouth guard works tirelessly to protect your teeth, gums, and jaw. But here’s the thing most people don’t realize: if you’re not cleaning it properly, the same guard that protects your oral health can easily turn into a trap for bacteria, fungi, and mold.
Think about it. You wear your guard for hours at a time, usually in warm, moist conditions, the perfect breeding ground for harmful microorganisms.
In this guide, we’ll learn easily how to clean a mouth guard, deeper cleaning methods for extra protection, storage tips, and even signs that it might be time for a replacement. By the end, you’ll know exactly how to care for your mouth guard without damaging it.
Quick Fact: A study confirmed that pathogens such as S. aureus and E. coli are present on mouthguard materials and can be effectively reduced using disinfectants like hand sanitizer or bleach.
Immediately Rinse after Every Use
The moment you take your mouth guard out, it’s already covered in saliva, bacteria, and sometimes leftover food particles from your last meal. If you simply toss it into its case or leave it lying around, all that buildup sticks to the surface and hardens. That sticky layer is a perfect invitation for germs to multiply.
That’s why rinsing immediately is the golden rule. A quick rinse under cool or lukewarm water takes less than a minute, yet it makes a world of difference. It washes away loose debris, reduces bacterial growth, and makes the next cleaning step far easier.
Here’s something important: never use hot water to rinse. Heat can warp the plastic, especially with custom-made guards that need a precise fit.
Daily Cleaning Methods
How to clean a mouth guard daily? Just like brushing your teeth, cleaning your mouth guard every day is not optional; it’s essential. Skipping even one day can cause odor, staining, and harmful bacterial buildup. The good news? You don’t need fancy products or complicated routines. Here are four dentist-approved methods you can rely on.
Toothpaste & Soft Brush
One of the easiest methods is to use toothpaste and a toothbrush. Choose soft bristles and a gentle, non-abrasive toothpaste. Whitening pastes or charcoal options should be avoided as they can scratch the surface of the guard, creating little grooves where bacteria can hide.
Take about a minute to gently scrub all surfaces. Once done, rinse thoroughly and let it air dry. This method is especially useful for people who grind their teeth at night.
Soap and Water
This is one of the most affordable and effective ways to keep your guard clean. All you need is mild, alcohol-free liquid soap and lukewarm water. Mix a drop of soap in water, dip your soft brush into the solution, and scrub gently. Rinse thoroughly until no soap residue is left.
Baking Soda Paste

If odor is your biggest concern, baking soda will be your best friend. Known as nature’s deodorizer, baking soda neutralizes smells while also cleaning. Mix equal parts baking soda and water to form a paste. Brush it onto your guard gently, rinse well, and let it dry.
This method not only gives your guard a clean feel but also keeps it smelling fresh, even after long-term wear.
Alcohol-Free Mouthwash Soak
Want that cool, minty feeling? Try soaking your mouth guard in a diluted mix of alcohol-free mouthwash and water (equal parts). Leave it for up to 30 minutes, then rinse and air dry.
Weekly/Monthly Deep Cleaning
Even if you clean daily, some bacteria can still hide in tiny grooves or scratches. That’s why deep cleaning occasionally is essential. Think of it like spring-cleaning your home; a deeper clean makes sure nothing harmful lingers behind.
Vinegar and Hydrogen Peroxide Method
This is a powerful yet safe combination. Start by soaking your mouth guard in distilled white vinegar for 30 minutes. Vinegar helps kill bacteria and loosen buildup. Rinse thoroughly with cool water, then soak it in 3% hydrogen peroxide for another 30 minutes. This second soak targets germs and brightens the surface. Finally, rinse again and air dry completely.
Using Denture Cleaners
Another great option is over-the-counter denture tablets. These are designed to clean oral appliances safely. Just drop one into a cup of water, soak your guard, and rinse thoroughly afterward. They’re convenient, affordable, and widely available in most pharmacies.
Storage and Case Care
Cleaning your guard is only half of the battle. Proper storage plays an equally important role in keeping it safe.
Always air dry your guard for at least 15 to 30 minutes before putting it away. Storing it wet creates a humid environment where mold and bacteria thrive. Use a ventilated case with small air holes for airflow. A closed, airtight container might seem protective, but it encourages bacterial growth.
And don’t forget about the case itself. Wash it every two to three days with mild soap and water. You can also wipe it with a disinfectant. A dirty case defeats the whole purpose of cleaning your guard.
Material & Safety Considerations
Not all cleaners are safe. Here’s what to avoid:
- Avoid hot water. It warps the guard and ruins the fit.
- Avoid alcohol-based mouthwash. It dries and cracks the material.
- Avoid bleach or harsh chemicals. These can weaken the plastic and cause discoloration.
Instead, stick to gentle, safe cleaners and always check the manufacturer’s care instructions, especially if you have a custom-made guard from your dentist.
Signs It’s Time to Replace Your Mouth Guard
Even the best care routine won’t make your mouth guard last forever. Over time, wear and tear take their toll.
You’ll know it’s time for a replacement if you notice:
- Cracks or small tears
- Warping that makes it fit loosely
- Rough bite surfaces from grinding
On average, a night guard (mouth guard for grinding teeth) can last between one and five years. Sports guards usually need yearly replacement because they endure more impact.
Think of it like a pair of running shoes: eventually, no matter how well you care for them, they lose their effectiveness and need to be swapped out.
Deep Clean Alternatives & Products
If you’re looking for extra convenience or a more advanced clean, there are other options worth exploring.
Over-the-Counter Cleaning Tablets
These are designed for retainers and dentures, but work perfectly for mouth guards. They provide a safe, deep clean without damaging the material.
Ultrasonic Cleaners

For a professional-level clean at home, Aligner32 ultrasonic cleaners are a worthwhile consideration. They use sound waves to break down bacteria and debris without scratching the guard. They’re more of an investment, but many people find the results worth it.

If you wear an Aligner32 mouth guard, proper cleaning is a must. Luckily, the Aligner32 Care Kit makes it easy; it comes with a Cleaner + Whitener solution, a pull tool, a protective case, and a set of chewies. Together, these essentials help you keep your mouth guard fresh, stain-free, and safe while making your aligner journey more comfortable and hygienic.
Dental Check-Up Reminder
Your dentist isn’t just there to check your teeth; they can also help you care for your mouth guard. At your regular check-ups, bring your guard with you. Dentists can give it a professional ultrasonic cleaning, check for fit issues, and let you know if it’s time for a replacement.
This step is especially important if you grind your teeth. Your dentist can spot early signs of wear and suggest solutions to protect both your night guard and your teeth.
Quick Summary & Best Practices
Keeping your mouth guard in top condition doesn’t have to be complicated. The key is consistency. Always rinse your guard after every use to wash away saliva and surface debris. Make it a habit to brush it daily with soft bristles and a mild, non-abrasive cleaner to prevent bacteria buildup. Just as important, be sure to let it dry completely before storing it in a ventilated case to avoid mold or odor. And remember, even with the best care, no mouth guard lasts forever, so replace it whenever you notice damage, warping, or persistent odors to keep your smile fully protected.
FAQs
1. What is the best way to sanitize a mouth guard?
Use a mild soap or baking soda for daily cleaning and a weekly deep clean with denture tablets or vinegar and hydrogen peroxide.
2. How often should you clean your nightly mouth guard?
Every single day after use to prevent bacteria buildup and odors.
3. Is it okay to soak my night guard in mouthwash?
Yes, but only in alcohol-free mouthwash, diluted with water, and for no longer than 30 minutes.
4. How to clean a night guard naturally?
Use baking soda paste or vinegar soak, rinse well, and air-dry, for safe, chemical-free cleaning.
5. How to wash a mouth guard?
Rinse after each use, gently brush with mild soap or toothpaste, then air-dry before storing.
Citations:
Haddad e Borro, L., de Queiroz, T. S., da Cruz, B. S., Demachkia, A. M., Borges, A. L. S., Tribst, J. P. M., & Paes Junior, T. J. A. (2024). Enhancing mouthguard longevity: Impact of surface treatment against aging from brushing and disinfectant exposure. Dental Traumatology. Advance online publication. https://doi.org/10.1111/edt.12941
D’Ercole, S., Tieri, M., Martinelli, D., Ciaravino, C., Fulco, D., & Tripodi, D. (2020). Microbial contamination and disinfection of sport mouthguard: In vitro study. Current Microbiology, 77(2), 246–253. https://doi.org/10.1007/s00284-019-01834-1
Glass, R. T., Conrad, R. S., Köhler, G. A., Warren, A. J., & Bullard, J. W. (2011). Microbiota found in protective athletic mouthguards. Sports Health, 3(3), 244–248. https://doi.org/10.1177/1941738111404869